6533b7d7fe1ef96bd1268ca5

RESEARCH PRODUCT

Pharmacological preconditioning in global cerebral ischemia

Oliver KempskiHolger NogaAnsgar M. BrambrinkAndreas AstheimerAxel Heimann

subject

Tolerance inductionNeocortexmedicine.anatomical_structurenervous systembusiness.industryTime courseIschemiamedicineHippocampusIschemic preconditioningPharmacologymedicine.diseasebusiness

description

Single dose 3-nitropropionic acid (3-NPA) 24 hr before global ischemia improves neuronal survival in both, neocortex and hippocampus (‘chemical preconditioning’). Neuronal survival after transient global ischemia requires new protein synthesis during recovery, especially of those with anti-apoptotic function. Bcl-2-protein is expressed in neurons that survive cerebral ischemia and may parallel the time course of tolerance after ischemic preconditioning. With this study we examined whether differences in bcl-2-protein expression compared to baseline may be involved in the induction of ischemic tolerance using 3-NPA.

https://doi.org/10.1007/978-3-7091-0603-7_8