6533b7d7fe1ef96bd12690e4

RESEARCH PRODUCT

Primary oral melanoma : a histopathological and immunohistochemical study of 22 cases of Latin America

Bruno-augusto-benevenuto De-andradeRoman CarlosElisa ContrerasWilson Delgado-azañeroOslei-paes De-almeidaAdalberto Mosqueda-taylorJorge-esquiche LeónVíctor-hugo Toral-rizo

subject

AdultMalePathologymedicine.medical_specialtyNecrosisProliferative indexPerineural invasionYoung AdultMART-1 AntigenmedicineHumansGeneral DentistryMelanomaAgedMouth neoplasmAged 80 and overOral Medicine and Pathologybusiness.industryMelanomaS100 ProteinsMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Immunohistochemistrymedicine.anatomical_structureKi-67 AntigenLatin AmericaOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASImmunohistochemistrySurgeryHistopathologyResearch-ArticleFemaleMouth NeoplasmsHard palatemedicine.symptombusinessMelanoma-Specific Antigensgp100 Melanoma Antigen

description

Objective: The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM). Study Design: Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67. Results: The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells. Conclusion: S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis. Key words:Oral melanoma, histopathology, immunohistochemistry.

yearjournalcountryeditionlanguage
2011-12-01
http://hdl.handle.net/10550/59950