6533b7d7fe1ef96bd1269101
RESEARCH PRODUCT
Comparative effects of UVA and UVB irradiation on the immune system of fish.
Heikki PenttiläS. Eveliina MarkkulaHarri M. SaloE. Ilmari JokinenT.m. Aaltonensubject
medicine.medical_specialtyUltraviolet RaysBiophysicsCyprinidaeImmunoglobulinsHematocritLymphocyte ActivationLeukocyte CountImmune systemInternal medicinemedicineAnimalsRadiology Nuclear Medicine and imagingLymphocytesRadiationHematologyintegumentary systemRadiological and Ultrasound Technologybiologymedicine.diagnostic_testGranulocytosisBlood Proteinsmedicine.diseaseMolecular biologyBlood proteinsBlood chemistryHematocritImmunologybiology.proteinErythrocyte Countsense organsAntibodyLymphocytopeniadescription
Aquatic organisms can be harmed by the current levels of solar ultraviolet radiation. We have recently shown that exposure of fish to UVB irradiation alters the functioning of the fish immune system, but the effects of UVA radiation are unknown. The present study continues this work by characterizing UVA irradiation-induced immunological changes in fish. Roach, a cyprinid fish, were exposed to a single dose of either UVA (3.6 J/cm2) or UVB (0.5 J/cm2) irradiation. Both irradiations suppressed transiently mitogen-stimulated proliferation of blood lymphocytes. UVA, but not UVB, decreased hematocrit, plasma protein, and plasma immunoglobulin levels and increased the proportions of blood cells classified as unidentified leukocytes, possibly consisting of UVA-damaged lymphocytes. UVB, but not UVA, altered the functioning of head kidney and blood phagocytes, induced granulocytosis and lymphocytopenia in the blood and increased plasma cortisol concentration. These results imply that both UVA and UVB are potent modulators of the immune defence of fish.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-07-01 | Journal of photochemistry and photobiology. B, Biology |