6533b7d8fe1ef96bd12697a5

RESEARCH PRODUCT

Über eine mangelnde Parallelität zwischen Ionenpumpenhemmung und Kontraktionskraftsteigerung

G. KuschinskyUwe WollertH. Lüllmann

subject

PharmacologyCellular and Molecular NeuroscienceChemistryStereochemistryMolecular MedicineIonic bondingCell BiologyMolecular BiologyMechanism (sociology)

description

Δ 5-Pregnen-3,20-dione-N,N'-ethylpyrrolidine-bisguanylhydrazone and Δ5-pregnen-3β-hydroxy-20-one-N,N'-ethyl-pyrrolidine-monoguanylhydrazone inhibit the activity of the ionic pump of cold-stored erythrocytes of guinea-pigs. The contractile force of isolated guinea-pig auricles is decreased by the mono-derivate and increased by the bis-derivate in spite of the similar action upon the pumping mechanism.

https://doi.org/10.1007/bf02150294