6533b7d8fe1ef96bd1269997

RESEARCH PRODUCT

Functionalized halloysite nanotubes: Efficient carrier systems for antifungine drugs

Giuseppe LazzaraMarina MassaroSerena RielaCarmelo Giuseppe CollettiRenato NotoAmbra Campofelice

subject

02 engineering and technologyengineering.material010402 general chemistry01 natural sciencesHalloysiteAdsorptionGeochemistry and PetrologymedicineMoleculeSettore CHIM/02 - Chimica Fisicachemistry.chemical_classificationCyclodextrinClotrimazoletechnology industry and agricultureFunctionalized halloysite Cyclodextrin Clotrimazole Drug carrierGeologySettore CHIM/06 - Chimica Organica021001 nanoscience & nanotechnology0104 chemical scienceschemistryChemical engineeringCovalent bondengineeringSurface modificationlipids (amino acids peptides and proteins)Nanocarriers0210 nano-technologymedicine.drug

description

Abstract Halloysite-cyclodextrin hybrid was employed as carrier for sustained release of clotrimazole for vaginal or buccal treatment of Candidiasis. The nanocarrier was obtained by functionalization of halloysite surface with cyclodextrin moieties by means of microwave irradiation, with the final goal to obtain a scaffold for the covalent linkage of cysteamine hydrochloride. The interaction between clotrimazole and the pristine components, namely cyclodextrin and halloysite, was thoroughly investigated by several techniques such as DSC, TGA, UV–vis spectroscopy and some adsorption studies were, also, carried out. The release of the antifungine molecule was finally investigated in a medium that imitates the physiological conditions.

yearjournalcountryeditionlanguage
2018-08-01Applied Clay Science
https://doi.org/10.1016/j.clay.2018.01.005