Anti-Idiotypic Antibodies Against the Kinin Receptor

6533b7d8fe1ef96bd12699c2

RESEARCH PRODUCT

Anti-Idiotypic Antibodies Against the Kinin Receptor

J Buschko Werner Müller-esterl J Hoebeke Alexander Faussner M Haasemann Burch R A A Roscher

subject

Pharmacology Idiotype medicine.drug_class Kinin Biology Ligand (biochemistry)Monoclonal antibody Molecular biology medicine Enzyme-linked receptor Paratope Bradykinin receptor Cardiology and Cardiovascular Medicine Receptor

description

Three sets of monoclonal antibodies against bradykinin (MBK1, MBK2, and MBK3) were generated by somatic cell fusion, characterized by their peptide specificity, and compared with the known ligand specificity of the kinin receptor subtypes. By these criteria, the paratope of MBK3 resembled the B 2 receptor binding site, whereas MBK1 shared principal binding characteristics with the B 1 receptor. Anti-idiotypic antibodies against MBK1, MBK2, and MBK3 were raised in rabbit and sheep

year	journal	country	edition	language
1992-12-01	Journal of Cardiovascular Pharmacology

https://doi.org/10.1097/00005344-199200209-00010

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