6533b7d8fe1ef96bd1269a74
RESEARCH PRODUCT
Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference
Nicola NicolaiDavide BiasoniMario A. CatanzaroMaurizio ColecchiaAnnalisa TramaMonika HacklElizabeth Van EyckenKris HenauNadya DimitrovaMario SekerijaLadislav DušekMargit MägiNea MalilaMaarit LeinonenMichel VeltenXavier TroussardVeronique BouvierAnne-valérie GuizardAnne-marie BouvierPatrick ArveuxMarc MaynadiéAnne-sophie WoronoffMichel RobaszkiewicIsabelle BaldiAlain MonnereauBrigitte TretarreMarc ColonnaFlorence MoliniéSimona BaraClaire SchvartzBénédicte Lapôtre-ledouxPascale GrosclaudeRoland StabenowSabine LuttmannAlice NenneckeJutta EngelGabriele Schubert-fritschleJan HeidrichBernd HolleczekJón Gunnlaugur JónassonKerri Clough-gorrHarry ComberGuido MazzoleniAdriano GiacominAntonella Sutera SardoAlessandr BarchielliDiego SerrainoRoberta De AngelisSandra MalloneAndrea TavillaDaniela PierannunzioSilvia RossiMariano SantaquilaniArnold KnijnFabio PannozzoValerio GennaroLucia BenfattoPaolo RicciMariangela AutelitanoGianbattista SpagnoliMario FuscoMario UsalaVitale FrancescoMaria MichiaraRosario TuminoLucia MangoneFabio FalciniStefano FerrettiRosa Angela FilibertiEnza MaraniArturo IannelliFlavio SensiSilvano PifferMaria GentiliniAnselmo MadedduAntonio ZiinoSergio MasperoPina CandelaFabrizio StracciGiovanna TagliabueMassimo RuggeAnnalisa TramaGemma GattaLaura BottaRiccardo CapocacciaSanta PildavaGiedre SmailyteNeville CallejaTom Børge JohannesenJadwiga RachtanStanisław GóźdźJerzy BłaszczykKamila KępskaGonçalo Forjaz De LacerdaMaria José BentoAna MirandaChakameh Safaei DibaEnrique AlmarNerea LarrañagaArantza Lopez De MunainAna Torrella-ramosJosé María Díaz GarcíaRafael Marcos-grageraMaria Josè SanchezCarmen NavarroDiego SalmeronConchi Moreno-iribasJaume GalceranMarià CarullaMohsen MousaviChristine BouchardySilvia M. EssAndrea BordoniIsabelle KonzelmannJem RashbassAnna GavinDavid BrewsterDyfed Wyn HuwsOtto VisserMagdalena Bielska-lasotaMaja Primic-zakeljIan KunklerEllen Benhamousubject
OncologyMaleSurvival030232 urology & nephrologyDiseaseCarcinoma; Community network; Europe; Germ cell and embryonal; Neoplasms; Penis neoplasms; Rare diseases; Squamous cell; Survival; Tertiary care centres; Testicular neoplasms; Surgery; Oncology0302 clinical medicineNeoplasmsEpidemiologyTesticular neoplasmReferral and ConsultationPenis neoplasmsCarcinoma ; Community network ; Europe ; Germ cell and embryonal ; Neoplasms ; Penis neoplasms ; Rare diseases ; Squamous cell ; Survival ; Tertiary care centres ; Testicular neoplasmsGeneral MedicineNeoplasms Germ Cell and EmbryonalTertiary care centreRare diseasesSurvival RateEuropeOncology030220 oncology & carcinogenesisLymphatic MetastasisCarcinoma Squamous CellHumanmedicine.medical_specialtyTesticular neoplasmsPenile squamous cell carcinomaGerm cell and embryonalCommunity networkSocio-culturaleCancer Care FacilitiesTertiary care centres03 medical and health sciencesPenis neoplasmRare DiseaseInternal medicinemedicineCarcinomaHumansPenile NeoplasmsNeoplasm StagingPenis Neoplasmsbusiness.industryCancer Care FacilitieSquamous cellCarcinomaLymphatic Metastasimedicine.diseaseTesticular germ cellAdult lifePenile NeoplasmProper treatmentNeoplasmLymph Node ExcisionSurgerybusinessDelivery of Health Caredescription
Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines- are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating. Deviation from recommended management may be a reason of a significant prognostic worsening, as proper treatment favourably impacts on these tumours, dramatically on GCT and significantly on PeSCC. RARECAREnet data may permit to analyse how survivals may vary according to geographical areas, histology and age, leading to assume that non-homogeneous health-care resources may impact the cure and definitive outcomes. In support of this hypothesis, some epidemiologic datasets and clinical findings would indicate that survival may improve when appropriate treatments are delivered, linked to a different accessibility to the best health institutions, as a consequence of geographical, cultural and economic barriers. Finally, strong clues based on epidemiological and clinical data support the hypothesis that treatment delivered at reference centres or under the aegis of a qualified multi-institutional network is associated with a better prognosis of patients with these malignancies. The ERN EURACAN represents the best current European effort to answer this clinical need.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 |