6533b7d8fe1ef96bd1269b01

RESEARCH PRODUCT

The accuracy of sentinel lymph node biopsy in the treatment of multicentric invasive breast cancer using a subareolar injection of tracer.

Renato CostaGiuseppa GraceffaMario Adelfio LatteriSalvatore VieniCalogero CipollaSalvatore FricanoStefania LatteriDaniela Cabibi

subject

Adultmedicine.medical_specialtyAxillary lymph nodesInjections IntradermalSentinel lymph nodeBreast NeoplasmsIsosulfan BlueSettore MED/08 - Anatomia PatologicaCohort StudiesBreast cancerPredictive Value of TestsBiopsymedicineRosaniline DyesHumansRadioactive TracersColoring AgentsTechnetium Tc 99m Aggregated AlbuminAgedRetrospective Studiesmedicine.diagnostic_testbusiness.industrySentinel Lymph Node BiopsyCarcinoma Ductal BreastReproducibility of ResultsSentinel Lymph Node Biopsy Multicentric Invasive Breast CancerMiddle Agedmedicine.diseaseSurgeryAxillaCarcinoma LobularSettore MED/18 - Chirurgia Generalemedicine.anatomical_structureSurgeryFemaleBreast diseaseRadiologyLymphRadiopharmaceuticalsbusiness

description

BACKGROUND: The aim of this study was to evaluate the feasibility and the accuracy of sentinel lymph node biopsy in multicentric breast cancer (MBC) performed by means of a subareolar (SA) injection of both 99Tc-labeled human albumin colloid and lymphazurin. METHODS: Between January 2002 and October 2007, 34 patients with MBC with clinically negative axilla underwent sentinel lymph node biopsy (SLNB) followed by total axillary node dissection (AD). Overall successful identification rate of SLN was 100%; there were no false negatives and overall accuracy rate was 100%. RESULTS: The mean number of sentinel lymph nodes (SLNs) identified was 1.8 +/- 0.88 (range = 1-4); the mean number of axillary lymph nodes examined was 21.4 +/- 5.76 (range = 8-36). CONCLUSIONS: The authors conclude that SA injection of the tracer is feasible and efficacious in the identification of the SLN. The accuracy of SLNB in MBC is comparable to that obtained in unifocal disease.

yearjournalcountryeditionlanguage
2008-08-30
10.1007/s00268-008-9719-1http://hdl.handle.net/10447/47987