6533b7d8fe1ef96bd1269ba0
RESEARCH PRODUCT
On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions
Mats JonssonMaria Antonietta SabatinoMarta WaloNatascia GrimaldiMaria Rosalia MangioneClelia DispenzaClelia DispenzaEagambaram Murugansubject
chemistry.chemical_classificationAqueous solutionirradiationManufacturing processGeneral Chemical EngineeringNanotechnology02 engineering and technologyGeneral ChemistryPolymerradiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers010402 general chemistry021001 nanoscience & nanotechnologyBiocompatible material01 natural sciences0104 chemical scienceschemistrySurface modificationSettore CHIM/07 - Fondamenti Chimici Delle TecnologieParticle sizeNanocarriers0210 nano-technologyhydrogelsNanogeldescription
Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |