6533b7d8fe1ef96bd126a1c7

RESEARCH PRODUCT

Low concentration of ziprasidone in human milk: a case report

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Although second-generation antipsychotics are established as the first-line treatment for schizophrenia, female patients are often excluded from this efficient treatment for safety reasons in pregnancy or whilst breastfeeding. For this reason, research on this subject mostly relies on case reports, although there is a great need to establish modern guidelines for treatment. Milk-to-plasma (M:P) ratios have been reported for clozapine (2.79–4.32; Winans, 2001), olanzapine (0.10–0.84; Gardiner et al. 2003), risperidone/9-OH risperidone (0.10–0.42/0.24–0.50; Gentile, 2004) and aripiprazole (0.18–0.20; Schlotterbeck et al. 2007). According to one case report, the infant ingests 0.09–0.43% of the weight-adjusted maternal dose of quetiapine (Lee et al. 2004). To our knowledge, this is the first report of ziprasidone in human breast milk. Mrs B, a 22-yr old woman (gravida I, para I) was admitted to our psychiatric hospital 7 d after giving birth to a healthy boy. She had not reported her psychiatric history to her gynaecologists, who were not aware that the patient had been diagnosed with schizophrenia. On showing peripartum agitation, anxiety and verbal aggression, the …