Aging-associated genes and let-7 microRNAs: a contribution to myogenic program dysregulation in oculopharyngeal muscular dystrophy

6533b7d8fe1ef96bd126a4e7

RESEARCH PRODUCT

Aging-associated genes and let-7 microRNAs: a contribution to myogenic program dysregulation in oculopharyngeal muscular dystrophy

Alessandra Renieri Pia Bernasconi Cristina Cappelletti Carmelo Rodolico Barbara Galbardi Marina Mora Eleonora Canioni Mirella Bruttini Maria Barbara Pasanisi Franco Salerno Lorenzo Maggi Renato Mantegazza Teresa Brizzi

subject

0301 basic medicine Male Aging Oculopharyngeal Muscle Development Biochemistry Myoblasts 0302 clinical medicine 80 and over Muscular Dystrophy HMGB1 Protein PAX7 Transcription Factor Cell Differentiation differentiation Middle Aged Cell biology medicine.anatomical_structure Female Myogenin Mitogen-Activated Protein Kinases Biotechnology Differentiation regeneration skeletal muscle Adult Biology Inclusion Body Oculopharyngeal muscular dystrophy 03 medical and health sciences microRNA Genetics medicine Humans Genetic Predisposition to Disease differentiation; regeneration; skeletal muscle; Adult; Aged; Aged 80 and over; Aging; Antigens Neoplasm; Cell Differentiation; Female; Gene Expression Regulation; HMGB1 Protein; Humans; Male; MicroRNAs; Middle Aged; Mitogen-Activated Protein Kinases; Muscle Development; Muscular Dystrophy Oculopharyngeal; Myoblasts; Myogenin; Myositis Inclusion Body; PAX7 Transcription Factor; Genetic Predisposition to Disease skeletal muscle Antigens Molecular Biology Gene Aged Messenger RNA Myositis Regeneration (biology)Skeletal muscle medicine.disease MicroRNAs 030104 developmental biology Muscle disease Gene Expression Regulation regeneration Neoplasm 030217 neurology & neurosurgery

description

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle disease caused by an abnormal (GCN) triplet expansion within the polyadenylate-binding protein nuclear 1 gene and consequent mRNA pr...

year	journal	country	edition	language
2019-03-12

10.1096/fj.201801577rr http://hdl.handle.net/11365/1126833

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