6533b7d8fe1ef96bd126ac87
RESEARCH PRODUCT
mdm2 mRNA expression is associated with survival in ovarian cancer
Paul Georg KnapsteinW. WeikelRoger BeckerJan G. HengstlerFranz OeschRolf MeinertBerno TannerSilke Laubschersubject
CisplatinCancer ResearchPathologymedicine.medical_specialtyChemotherapyendocrine system diseasesCyclophosphamidemedicine.medical_treatmentOvaryBiologymedicine.diseasefemale genital diseases and pregnancy complicationsCarboplatinNitrogen mustardchemistry.chemical_compoundmedicine.anatomical_structureOncologychemistryCarcinomamedicineCancer researchOvarian cancermedicine.drugdescription
Expression of mdm-2 mRNA was measured in 90 ovarian-cancer tissue specimens using the S1 nuclease assay, to investigate a possible association between MDM2 expression and prognosis. mdm-2 mRNA expression was an independent prognostic factor for patients with primary ovarian cancer, FIGO (International Federation of Gynecology and Obstetrics) stages III and IV (n = 57), who all received chemotherapy with carboplatin or cisplatin and cyclophosphamide. Median survival time for patients (FIGO stages III and IV) with no detectable expression of mdm-2 mRNA (n = 14) was 171 days, as compared with 839 days for patients (n = 43) with detectable mdm-2 mRNA (p = 0.0194; log-rank test). However, no association between mdm-2 mRNA expression and survival was observed for patients with FIGO stages I and II who did not receive chemotherapy. mdm-2 expression was not associated with FIGO stage, residual disease, histologic grade and type. Our results suggest that mdm-2, which is known to disrupt p53 function, sensitizes ovarian-cancer cells to cisplatin/cyclophosphamide, possibly by inhibition of p53-mediated G1 cell-cycle arrest and p53-stimulated nucleotide-excision repair.
year | journal | country | edition | language |
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1997-08-22 | International Journal of Cancer |