6533b7d8fe1ef96bd126ae21

RESEARCH PRODUCT

Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters

ÁLvaro Carrasco-garcíaGonzalo Pin-arboledasMarie GombertJoaquín Carrasco-lunaVanessa Martin-carbonellPilar Codoñer-franch

subject

LeptinMalePediatric Obesitymedicine.medical_specialtyAdolescentAdipokinemelatoninArticleChildhood obesityMelatoninInterferon-gammaAdipokinesInternal medicinePlasminogen Activator Inhibitor 1medicinelow-grade inflammationHumansTX341-641Circadian rhythmChildSalivaChemokine CCL2InflammationNutrition and DieteticsTumor Necrosis Factor-alphabusiness.industryNutrition. Foods and food supplyLeptinmedicine.diseaseObesityGhrelinCircadian RhythmC-Reactive ProteinEndocrinologycircadian rhythmsFemaleGhrelinSleepbusinessPlasminogen activatorchildhood obesitymetabolismFood Sciencemedicine.drug

description

Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during childhood are scarce. The present study investigated the association of melatonin with metabolic and inflammatory markers in children with (n = 113) and without obesity (n = 117). Melatonin was measured in saliva four and two hours before bedtime, and after one hour of sleep. Cardiometabolic factors, high sensitivity C-reactive protein, immune markers (monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, tumor necrosis α and interferon-γ), leptin and ghrelin were determined. Sleep duration was recorded by a questionnaire. The melatonin level at 1 h after sleep was found to be increased more than twofold in children with obesity (90.16 (57.16–129.16) pg/mL) compared to controls (29.82 (19.05–61.54) pg/mL, p &lt

yearjournalcountryeditionlanguage
2021-10-16Nutrients
10.3390/nu13103629https://www.mdpi.com/2072-6643/13/10/3629