6533b7d8fe1ef96bd126b80f
RESEARCH PRODUCT
A Case of Cardiomyopathy Due to Premature Ductus Arteriosus Closure: The Flip Side of Paracetamol.
Giovanni CorselloEttore PiroMario GiuffrèSimona La PlacaIngrid Anne Mandy Schierzsubject
Polyphenolmedicine.medical_specialtyDuctus ArteriosuVentricular Dysfunction RightCardiomyopathyHeart MurmurPulmonary Valve StenosiSelf MedicationDiet Mediterranean03 medical and health sciences0302 clinical medicinePregnancy030225 pediatricsInternal medicineDuctus arteriosusmedicineHumansVasoconstrictor AgentsAdverse effectCardiomyopathieAcetaminophenPregnancy030219 obstetrics & reproductive medicineHeart Murmursbusiness.industryDuctus arteriosus closureInfant NewbornPolyphenolsDuctus ArteriosusAnalgesics Non-Narcoticmedicine.diseaseAcetaminophenPulmonary Valve Stenosismedicine.anatomical_structurePrenatal Exposure Delayed EffectsPediatrics Perinatology and Child HealthPulmonary valve stenosiscardiovascular systemCardiologyHeart murmurFemalemedicine.symptomVasoconstrictor AgentbusinessCardiomyopathiesmedicine.drugHumandescription
Paracetamol (acetaminophen or N-acetyl-p-aminophenol) is considered a safe analgesic and antipyretic nonsteroidal antiinflammatory drug commonly used during pediatric ages and during pregnancy. We report on a term neonate with closed ductus arteriosus, severe cardiomyopathy, right ventricular dysfunction, and functional stenosis of pulmonary arteries at birth after maternal self-medication with paracetamol and consumption of polyphenol-rich foods in late pregnancy. This drug, especially when associated with other vasoconstrictors (such as polyphenols), interferes with prostaglandin metabolism, which seriously accentuates the intrauterine ductus arteriosus constriction and leads to pharmacologic adverse events. We suggest maternal educational programs to avoid risky self-medications and provide training for the best diets.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-03-24 | Pediatrics |