Fixed oil from seeds of narrow-leaved ash (F. angustifolia subsp. angustifolia): Chemical profile, antioxidant and antiproliferative activities.

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RESEARCH PRODUCT

Fixed oil from seeds of narrow-leaved ash (F. angustifolia subsp. angustifolia): Chemical profile, antioxidant and antiproliferative activities.

Massimo Ricciutelli Filippo Maggi Deborah Pacetti Monica Rosa Loizzo Rosario Schicchi Sergio Rosselli Anna Geraci Alessandra Giardinieri Dennis Fiorini Maurizio Bruno

subject

Polyphenol Antioxidant 030309 nutrition & dietetics Linoleic acid medicine.medical_treatment Fixed oil Antiproliferative activity Fraxinus angustifolia Antioxidants Settore BIO/01 - Botanica Generale 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Nutraceutical Antioxidant activity Glucosides Phenols Biological property medicine Hydroxybenzoates Oils Volatile Plant Oils Settore BIO/15 - Biologia Farmaceutica Food science Fraxinus angustifolia subsp. angustifolia chemistry.chemical_classification Flavonoids 0303 health sciences ABTS biology Plant Extracts Settore BIO/02 - Botanica Sistematica Fatty Acids Glycoside Melanoma Amelanotic Settore CHIM/06 - Chimica Organica 04 agricultural and veterinary sciences Phenylethanoid Fatty acid biology.organism_classification 040401 food science chemistry Seeds Volatile substances Food Science Oleic Acid

description

Fraxinus angustifolia subsp. angustifolia is a plant with an age-old use for the production of manna. However, it is also a valuable source of fixed oil rich-seeds. In the present study we examined the chemical and biological properties of this oil in order to support a possible application in foodstuffs, nutraceuticals and cosmetics. Fatty acid composition, volatile and phenolic substances were evaluated. Oleic and linoleic acid represented 45.5% and 50.0%, respectively, of the total fatty acid composition. Among polar phenolic substances identified (secoiridoids, phenylethanoid glycosides, phenolic acids and alcohols, flavonoids, coumarins) isoverbascoside is for the first time reported in this species. Volatiles were mainly characterized by sesquiterpenes. The oil showed good antioxidant activity, in terms of ABTS radical scavenging activity, with an IC 50 value of 28.2 μg/mL. The antiproliferative activity was also investigated: amelanotic melanoma (C32) and lung carcinoma (A549) cells were the most sensitive with IC 50 values comparable to that of the positive control vinblastine. These findings shed light on the potential use of F. angustifolia subsp. angustifolia fixed oil in nutraceutics and cosmetics.

year	journal	country	edition	language
2019-01-01	Food research international (Ottawa, Ont.)

10.1016/j.foodres.2019.02.013 https://pubmed.ncbi.nlm.nih.gov/30884667