6533b7d8fe1ef96bd126b881
RESEARCH PRODUCT
How miR-31-5p and miR-33a-5p Regulates SP1/CX43 Expression in Osteoarthritis Disease: Preliminary Insights
Angela De LucaAlice ConigliaroViviana CostaFrancesca SalamannaMarcello De FineGianluca GiavaresiRiccardo AlessandroDaniele BellaviaMilena FiniValeria CarinaGiovanni PignattiLavinia Raimondisubject
Male0301 basic medicineBone diseasechondrocytesOsteoarthritisCX43lcsh:Chemistry0302 clinical medicinelcsh:QH301-705.5Cells CulturedSpectroscopymicroRNAosteoblastsGeneral MedicineMiddle AgedPrognosisComputer Science ApplicationsmicroRNAsmir-31030220 oncology & carcinogenesischondrocyteosteoblastFemalemedicine.symptomSignal TransductionAdultSp1 Transcription FactorInflammationBiologyArticleCatalysisInorganic Chemistry03 medical and health sciencesmicroRNAmedicineHumansPhysical and Theoretical ChemistryBone regenerationMolecular BiologyGeneLoss functionAgedOrganic Chemistrymedicine.diseaseSP1osteoarthritis030104 developmental biologyGene Expression Regulationlcsh:Biology (General)lcsh:QD1-999Connexin 43Cancer researchFollow-Up Studiesdescription
Osteoarthritis (OA) is a degenerative bone disease that involved micro and macro-environment of joints. To date, there are no radical curative treatments for OA and novel therapies are mandatory. Recent evidence suggests the role of miRNAs in OA progression. In our previous studies, we demonstrated the role of miR-31-5p and miR-33a families in different bone regeneration signaling. Here, we investigated the role of miR-31-5p and miR-33a-5p in OA progression. A different expression of miR-31-5p and miR-33a-5p into osteoblasts and chondrocytes isolated from joint tissues of OA patients classified in based on different Kellgren and Lawrence (KL) grading was highlighted
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-28 | International Journal of Molecular Sciences |