6533b7d9fe1ef96bd126b8ed

RESEARCH PRODUCT

Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders.

Dario SiniscalcoNazarii KobyliakVanda ValentovaNadezda StollárováIveta GasparovaLuis RodrigoMartin CaprndaDietrich BüsselbergJozef DragasekRobert ProseckyIoana MozosPeter KubatkaKatarina GazdikovaGiampiero La RoccaPeter Kruzliak

subject

0301 basic medicineSettore BIO/17 - IstologiaPathologymedicine.medical_specialtymedicine.medical_treatmentRegenerative medicineModels Biological03 medical and health sciencesmedicineAnimalsHumansImmunologic FactorsInduced pluripotent stem cellPharmacologyStem cell therapybusiness.industryMultiple sclerosisStem CellsMesenchymal stem cellNeurodegenerative DiseasesGeneral MedicineStem-cell therapyNeurodegenerative disordermedicine.diseaseEmbryonic stem cellNeural stem cell030104 developmental biologyRegenerative medicineStem cellbusinessNeuroscienceStem Cell Transplantation

description

Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities.

yearjournalcountryeditionlanguage
2017-02-27Biomedicinepharmacotherapy = Biomedecinepharmacotherapie
10.1016/j.biopha.2017.04.034https://pubmed.ncbi.nlm.nih.gov/28448871