6533b7d9fe1ef96bd126b91e

RESEARCH PRODUCT

Pharmacological Characterization of Melanocortin Receptors in Fish Suggests an Important Role for ACTH

Janis KlovinsJanis KlovinsTatjana HaitinaHelgi B. Schiöth

subject

endocrine systemmedicine.medical_specialtyanimal structuresAlpha (ethology)BiologyGeneral Biochemistry Genetics and Molecular BiologyAdrenocorticotropic HormoneHistory and Philosophy of ScienceInternal medicinemedicineAnimalsHumansACTH receptorReceptorBeta (finance)G protein-coupled receptorintegumentary systemFuguReceptors MelanocortinGeneral NeurosciencefungiFishesMelanocortin 3 receptorCell biologyEndocrinologyMelanocortinhormones hormone substitutes and hormone antagonistsProtein Binding

description

The melanocortin (MC) receptor subtypes have distinctive characteristic binding profiles. We found that the trout and Fugu MC4 receptors have similar affinity for alpha-MSH and beta-MSH and a much higher affinity for ACTH than does the human MC4 receptor. The Fugu MC1 and the trout and Fugu MC5 receptors also have higher affinity for ACTH-derived peptides than alpha-, beta-, or gamma-MSH. It is tempting to speculate that ACTH-derived peptides may have played an important role as "original" ligands at the MC receptors, while the specificity of the different subtypes for the alpha-, beta-, and gamma-MSH peptides may have appeared at later stages during vertebrate evolution.

yearjournalcountryeditionlanguage
2005-04-01Annals of the New York Academy of Sciences
https://doi.org/10.1196/annals.1327.055