6533b7d9fe1ef96bd126c046
RESEARCH PRODUCT
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
Albrecht LindemannWolfgang OsterRoland MertelsmannFriedhelm HerrmannWolf-dieter Ludwigsubject
education.field_of_studybusiness.industrymedicine.medical_treatmentImmunologyPopulationCell BiologyHematologymedicine.diseaseBiochemistryPancytopeniaHaematopoiesisCytokinemedicine.anatomical_structureImmunologymedicineHairy CellTumor necrosis factor alphaHairy cell leukemiaBone marrowbusinesseducationdescription
Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-03-01 | Blood |