Long-Term Clinical Outcomes According to Previous Manifestations of Atherosclerotic Disease (from the FAST-MI 2010 Registry)

6533b7d9fe1ef96bd126c1fd

RESEARCH PRODUCT

Long-Term Clinical Outcomes According to Previous Manifestations of Atherosclerotic Disease (from the FAST-MI 2010 Registry)

Etienne Puymirat Etienne Puymirat Nicolas Danchin Nicolas Danchin Yves Cottin Nadia Aissaoui Tabassome Simon Jean Ferrières Jean Ferrières Gilles Lemesle Francois Schiele Pierre Coste

subject

Male MESH : Atherosclerosis medicine.medical_treatment MESH : Mortality Myocardial Infarction MESH : Aged MESH : Prospective Studies Angiotensin-Converting Enzyme Inhibitors Coronary Artery Disease Disease MESH : Cerebrovascular Disorders 0302 clinical medicine Medicine Longitudinal Studies Prospective Studies MESH: Coronary Artery Disease Myocardial infarction Coronary Artery Bypass MESH: Treatment Outcome Cause of death Aged 80 and over education.field_of_study MESH: Middle Aged Hazard ratio MESH : Platelet Aggregation Inhibitors Prognosis MESH: Case-Control Studies 3. Good health MESH: Myocardial Infarction MESH: Angiotensin Receptor Antagonists MESH : Angiotensin-Converting Enzyme Inhibitors Cardiology and Cardiovascular Medicine MESH: Percutaneous Coronary Intervention MESH : Case-Control Studies medicine.medical_specialty MESH : Angiotensin Receptor Antagonists MESH: Prognosis 03 medical and health sciences Percutaneous Coronary Intervention [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Humans MESH : Middle Aged MESH : Coronary Artery Disease MESH : Aged 80 and over MESH: Hydroxymethylglutaryl-CoA Reductase Inhibitors education MESH: Age Distribution Aged MESH: Humans MESH: Mortality Proportional hazards model MESH: Coronary Artery Bypass MESH : Humans Case-control study MESH : Proportional Hazards Models medicine.disease MESH : Coronary Artery Bypass Case-Control Studies MESH: Female MESH: Registries MESH : Age Distribution 030204 cardiovascular system & hematology MESH: Atherosclerosis MESH: Proportional Hazards Models MESH: Cause of Death MESH: Aged 80 and over MESH : Percutaneous Coronary Intervention Risk Factors MESH: Risk Factors Cause of Death MESH : Female Registries 030212 general & internal medicine MESH: Longitudinal Studies MESH : Longitudinal Studies MESH: Aged MESH : Prognosis MESH: Angiotensin-Converting Enzyme Inhibitors MESH: Adrenergic beta-Antagonists Middle Aged [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system MESH : Risk Factors Treatment Outcome MESH: Platelet Aggregation Inhibitors Cardiology Female MESH: Cerebrovascular Disorders France MESH : Male Adrenergic beta-Antagonists MESH : Adrenergic beta-Antagonists Population MESH : Treatment Outcome MESH: Multivariate Analysis Angiotensin Receptor Antagonists Age Distribution Internal medicine Mortality MESH : France Proportional Hazards Models MESH : Cause of Death business.industry MESH : Hydroxymethylglutaryl-CoA Reductase Inhibitors MESH : Multivariate Analysis Percutaneous coronary intervention Atherosclerosis MESH: Male MESH: Prospective Studies MESH: France Cerebrovascular Disorders Multivariate Analysis Hydroxymethylglutaryl-CoA Reductase Inhibitors MESH : Myocardial Infarction business Platelet Aggregation Inhibitors MESH : Registries

description

IF 3.398; International audience; The prognosis of patients with acute myocardial infarction (AMI) has notably improved in the past 20 years. Using the French Registry of ST-Elevation and Non-ST-elevation Myocardial Infarction (FAST-MI) 2010 registry, we investigated whether previous manifestations of atherosclerotic disease (i.e., previous MI, or a history of any form of atherosclerotic disease) are at truly increased risk compared with those in whom AMI is the first manifestation of the disease. FAST-MI 2010 is a nationwide French registry including 3,079 patients with AMI, among whom 1,062 patients had a history of cardiovascular atherosclerotic disease and 498 patients had a history of MI. Overall, patients with a history of atherosclerotic disease (or MI) were older compared with patients without known cardiovascular disease (71 ± 13 vs 63 ± 14 years) and had higher cardiovascular risk profiles and co-morbidities. Using fully adjusted Cox multivariate analysis, previous manifestations of atherosclerotic disease were associated with higher 3-year mortality (hazard ratio 1.80, 95% confidence interval 1.40 to 2.31; p <0.001) as history of previous MI alone (hazard ratio 1.32, 95% confidence interval 1.00 to 1.73; p = 0.048). Similar results were found in patients discharged alive. In conclusion, previous cardiovascular atherosclerotic disease represents 1/3 of patients with AMI and are strongly associated with worse long-term clinical outcomes. Intensive follow-up and therapy should be encouraged in this high-risk population.

year	journal	country	edition	language
2017-03-01	The American Journal of Cardiology

https://doi.org/10.1016/j.amjcard.2016.11.032