Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases

6533b7d9fe1ef96bd126c27d

RESEARCH PRODUCT

Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases

Caterina Maria Gambino Walter Mazzucco Laura Cristaldi Danilo Di Bona Giulia Accardi Rosanna Cusimano Giovanni Duro Calogero Caruso Anna Aiello Stefano Aprile Damiano Galimberti Mattia Emanuela Ligotti Sonya Vasto Giuseppina Candore

subject

Gerontology Aging Genotype media_common.quotation_subject Settore MED/42 - Igiene Generale E Applicata Age-related diseases; Sicily; body composition; genetics; immunosenescence; longevity 01 natural sciences 03 medical and health sciences longevity Age related Surveys and Questionnaires Drug Discovery Genotype Medicine Humans Life Style Sicily 030304 developmental biology media_common Pharmacology immunosenescence Settore MED/04 - Patologia Generale 0303 health sciences age-related disease body composition business.industry Translational medicine Longevity Immunosenescence language.human_language 0104 chemical sciences 010404 medicinal & biomolecular chemistry Phenotype Ageing language Identification (biology)genetic business Sicilian

description

Background:It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to a long and healthy life is of tremendous interest for translational medicine.Methods:We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long-lived individuals.Results:We review the characteristics of longevity in Sicily, taking into account lifestyle, environment, genetics, hematochemical values, body composition and immunophenotype. In addition, we discuss the possible implications of our data for the prevention and/or treatment of age-related diseases.Conclusion:As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and/or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a “positive biology” approach, how to prevent and/or reduce elderly frailty and disability.

year	journal	country	edition	language
2019-01-01

10.2174/1381612825666190313115233 http://hdl.handle.net/10447/356469