6533b7d9fe1ef96bd126cab6
RESEARCH PRODUCT
TLRs control hematopoiesis during infection
M. Luisa GilDaniel GozalboHelen S. GoodridgeAlberto Yáñezsubject
Innate immune systemMyeloidCellular differentiationImmunologyStem cell factorBiologyCell biologyHaematopoiesismedicine.anatomical_structureImmunologymedicineImmunology and AllergyProgenitor cellSignal transductionReceptordescription
Recent research has shown that (i) Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to proliferate and differentiate along the myeloid lineage in vitro, and (ii) direct TLR-mediated stimulation of HSPCs also promotes macrophage differentiation in vivo following infection. These new insights demonstrate that TLR signaling in HSPCs, in addition to other TLR-dependent mechanisms, can contribute to HSPC expansion and myeloid differentiation after infection. Evidence is, therefore, mounting that direct TLR-induced programming of hematopoiesis plays a key role in host defense by rapidly replenishing the innate immune system with the cells needed to deal with pathogens.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-10-01 | European Journal of Immunology |