6533b7d9fe1ef96bd126cb00
RESEARCH PRODUCT
Triterpene Saponins from the Roots of Achyranthes bidentata
Hildebert WagnerBruno ChauffertT.c. KhanhAbderrazak MaroufMaria CorreiaS. DesbeneMarie-aleth Lacaille-duboissubject
Pharmacologychemistry.chemical_classificationTraditional medicineSaponinPharmaceutical ScienceBiological activityGeneral MedicineAmaranthaceaeBiologybiology.organism_classificationIn vitroComplementary and alternative medicinechemistryTriterpeneDrug DiscoveryMolecular MedicineAchyranthesCytotoxicityAchyranthes bidentatadescription
Three saponins, oleanolic acid-28- O -s-D-glucopyranoside (1), chikusetsusaponin V (2), and 3- O -s-D-glucopyranosyl-oleanolic acid-28- O -s-D-glucopyranoside (3) were isolated from the roots of Achyranthes bidentata Blume (Amaranthaceae). No activity was shown in the granulocyte phagocytosis test nor in the test of the potentiation of the cytotoxicity of cisplatin in human colon cancer cells. This is the first report of compounds 1, 2 and 3 isolated from Achyranthes species. Furthermore, the NMR data of 2 completed the partially published data.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-01-01 | Pharmaceutical Biology |