Search results for "Achyranthes"

showing 4 items of 4 documents

ChemInform Abstract: Two Triterpene Saponins from Achyranthes bidentata.

2010

Bidentatoside II (1) and chikusetsusaponin V methyl ester (2) are two further triterpene saponins isolated from the roots of Achyranthes bidentata. Chemical and homo and heteronuclear two-dimensional (2D) NMR techniques have led to the structural elucidation of 1 which is a new seco-glycoside of oleanolic acid and the full 1H- and 13C-NMR assignments of 2. These compounds did not show any potentiation of the in vitro cytotoxicity of cisplatin in the HT 29 human colon cancer cell line.

Cisplatinchemistry.chemical_classificationbiologyGeneral Medicinebiology.organism_classificationTerpenechemistry.chemical_compoundchemistryBiochemistryHeteronuclear moleculeTriterpeneCell culturemedicineChikusetsusaponin VOleanolic acidAchyranthes bidentatamedicine.drugChemInform
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Bidentatoside I, a New Triterpene Saponin from Achyranthes bidentata

2001

Bidentatoside I (1) is a new triterpene saponin bearing an unusual dioxopropionic acid unit, isolated from the roots of Achyranthes bidentata. Structural elucidation was performed mainly by chemical and homo- and heteronuclear 2D NMR techniques. This compound did not show any potentiation of the in vitro cytotoxicity of cisplatin in the HT 29 human colon cancer cell line.

Magnetic Resonance SpectroscopyStereochemistrySaponinPharmaceutical ScienceAntineoplastic AgentsUronic acidPharmacognosyAnalytical ChemistryMagnoliopsidachemistry.chemical_compoundTriterpeneDrug DiscoveryTumor Cells CulturedHumansAchyranthes bidentataPharmacologychemistry.chemical_classificationbiologyOrganic ChemistryGlycosideSaponinsbiology.organism_classificationTriterpenesTerpenoidModels ChemicalComplementary and alternative medicinechemistryBiochemistryHeteronuclear moleculeColonic NeoplasmsMolecular MedicineDrug Screening Assays AntitumorJournal of Natural Products
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Triterpene Saponins from the Roots of Achyranthes bidentata

2001

Three saponins, oleanolic acid-28- O -s-D-glucopyranoside (1), chikusetsusaponin V (2), and 3- O -s-D-glucopyranosyl-oleanolic acid-28- O -s-D-glucopyranoside (3) were isolated from the roots of Achyranthes bidentata Blume (Amaranthaceae). No activity was shown in the granulocyte phagocytosis test nor in the test of the potentiation of the cytotoxicity of cisplatin in human colon cancer cells. This is the first report of compounds 1, 2 and 3 isolated from Achyranthes species. Furthermore, the NMR data of 2 completed the partially published data.

Pharmacologychemistry.chemical_classificationTraditional medicineSaponinPharmaceutical ScienceBiological activityGeneral MedicineAmaranthaceaeBiologybiology.organism_classificationIn vitroComplementary and alternative medicinechemistryTriterpeneDrug DiscoveryMolecular MedicineAchyranthesCytotoxicityAchyranthes bidentataPharmaceutical Biology
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Two Triterpene Saponins from Achyranthes bidentata.

2001

Bidentatoside II (1) and chikusetsusaponin V methyl ester (2) are two further triterpene saponins isolated from the roots of Achyranthes bidentata. Chemical and homo and heteronuclear two-dimensional (2D) NMR techniques have led to the structural elucidation of 1 which is a new seco-glycoside of oleanolic acid and the full 1H- and 13C-NMR assignments of 2. These compounds did not show any potentiation of the in vitro cytotoxicity of cisplatin in the HT 29 human colon cancer cell line.

StereochemistrySaponinPharmacognosyPlant Rootschemistry.chemical_compoundGlucosideTriterpeneDrug DiscoveryHumansOleanolic acidAchyranthes bidentataAchyrantheschemistry.chemical_classificationbiologyPlant ExtractsGlycosideGeneral ChemistryGeneral MedicineSaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicTriterpenesTerpenoidBiochemistrychemistryHT29 CellsChemical and Pharmaceutical Bulletin
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