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RESEARCH PRODUCT
Two Triterpene Saponins from Achyranthes bidentata.
Marie Aleth Lacaille-duboisNicolas BirlirakisBernard HanquetAnne Claire Mitaine-offerAbderrazak Maroufsubject
StereochemistrySaponinPharmacognosyPlant Rootschemistry.chemical_compoundGlucosideTriterpeneDrug DiscoveryHumansOleanolic acidAchyranthes bidentataAchyrantheschemistry.chemical_classificationbiologyPlant ExtractsGlycosideGeneral ChemistryGeneral MedicineSaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicTriterpenesTerpenoidBiochemistrychemistryHT29 Cellsdescription
Bidentatoside II (1) and chikusetsusaponin V methyl ester (2) are two further triterpene saponins isolated from the roots of Achyranthes bidentata. Chemical and homo and heteronuclear two-dimensional (2D) NMR techniques have led to the structural elucidation of 1 which is a new seco-glycoside of oleanolic acid and the full 1H- and 13C-NMR assignments of 2. These compounds did not show any potentiation of the in vitro cytotoxicity of cisplatin in the HT 29 human colon cancer cell line.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-11-29 | Chemical and Pharmaceutical Bulletin |