6533b7d9fe1ef96bd126ccd0
RESEARCH PRODUCT
Synthesis of pyrazole-4-carbohydrazide derivatives of pharmaceutical interest
Benedetta MaggioDemetrio RaffaFabiana PlesciaGiuseppe DaidoneAngela Roccarosubject
lcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistrychemistryIntramolecular forceOrganic ChemistryHydrazineMoleculePyrazoleCarbohydrazideEthyl esterHydrateMedicinal chemistrydescription
New 1-phenylor 1-methyl-5-benzamidopyrazole-4-carbohydrazide derivatives were prepared in 70–90% yields from 1-methylor 1-phenyl-6-phenylpyrazolo[3,4-d]1,3-oxazin-4(1H)-one derivatives and hydrazine hydrate. Small quantities of the isomeric 5-aminopyrazole-4-(Nbenzoyl)hydrazides were detected in some reaction mixtures, proving that intramolecular benzoyl migration can take place in the 5-benzamidopyrazole-4-carbohydrazide molecule. The direct formation of pyrazole-4-carbohydrazides from 5-benzamidopyrazole-4-carboxylic acid ethyl esters and hydrazine hydrate was unsuccessful.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-01-03 | Arkivoc |