Search results for "Carbohydrazide"
showing 10 items of 11 documents
Synthesis of pyrazole-4-carbohydrazide derivatives of pharmaceutical interest
2003
New 1-phenylor 1-methyl-5-benzamidopyrazole-4-carbohydrazide derivatives were prepared in 70–90% yields from 1-methylor 1-phenyl-6-phenylpyrazolo[3,4-d]1,3-oxazin-4(1H)-one derivatives and hydrazine hydrate. Small quantities of the isomeric 5-aminopyrazole-4-(Nbenzoyl)hydrazides were detected in some reaction mixtures, proving that intramolecular benzoyl migration can take place in the 5-benzamidopyrazole-4-carbohydrazide molecule. The direct formation of pyrazole-4-carbohydrazides from 5-benzamidopyrazole-4-carboxylic acid ethyl esters and hydrazine hydrate was unsuccessful.
ChemInform Abstract: Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies.
2009
The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties. Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters. Compounds 8a, b, 10a-d, and 11a, b revealed a superior inhibitory profile against COX-2, when compared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.
Intramolecular 1,5-S...N σ-hole interaction in (E)-N′-(pyridin-4-ylmethylidene)thiophene-2-carbohydrazide
2020
The hydrazide-hydrazone forms inverse dimers via hydrogen bonding, but its conformation is defined by the presence of an intramolecular chalcogen bond. Electrostatic forces dominate in the crystal packing and give rise to a layered supramolecular structure.
1,2,4-Triazoles. Improved synthesis of 5-substituted 4-amino-3-mer-cato-(4H)-1,2,4-triazoles and a facile route to 3,6-disubstituted 1,2,4-triazolo[3…
1997
The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the S-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles. The crude 4-amino-5-mercapto-1,2,4-triazoles react easily with carboxylic acids or carboxylic acid chlorides to afford the 1,2,4-triazolo[3,4-fc][1,3,4]thiadiazole ring system.
Coordination versatility of 1,5-bis(salicylidene)carbohydrazide in Ni(II) complexes
2014
Abstract Versatile coordination behavior of a polydentate Schiff base ligand 1,5-bis(salicylidene)carbohydrazide (H3bsc) has been explored in Ni(II) complexes. [Ni(H3bsc)2](ClO4)2 (1)·H2O·3CH3CN is a bis chelate mononuclear complex of H3bsc in keto form, and [Ni4(H0.5bsc)2(O2CCMe3)3(CH3OH)4](2)·2H2O·2CH3OH is a tetranuclear complex of H3bsc with an unusual coordination. In 2, one phenolate group of the ligand coordinates in a monodentate way and the other coordinates in a μ2-bridging mode to the Ni(II) center. This unusual coordination mode of the ligand stabilizes the Ni(II) complex in a tetranuclear form where the carbonyl oxygen of the ligand exists in between keto and enol form of bond …
Pyrazolo[3,4‐d]pyrimidine Derivatives as COX‐2 Selective Inhibitors: Synthesis and Molecular Modelling Studies
2009
The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties. Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters. Compounds 8a, b, 10a-d, and 11a, b revealed a superior inhibitory profile against COX-2, when compared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.
CCDC 1587259: Experimental Crystal Structure Determination
2019
Related Article: P. Sivajeyanthi, B. Edison, K. Balasubramani, G. Premkumar, T. Swu|2019|Acta Crystallogr.,Sect.E:Cryst.Commun.|75|804|doi:10.1107/S2056989019006492
CCDC 799323: Experimental Crystal Structure Determination
2012
Related Article: L.Brelot, Xiao-yu Cao, J.Harrowfield, J.-M.Lehn, K.Rissanen, L.Russo|2011|CrystEngComm|13|2346|doi:10.1039/c0ce00814a
CCDC 799324: Experimental Crystal Structure Determination
2012
Related Article: L.Brelot, Xiao-yu Cao, J.Harrowfield, J.-M.Lehn, K.Rissanen, L.Russo|2011|CrystEngComm|13|2346|doi:10.1039/c0ce00814a
CCDC 1432912: Experimental Crystal Structure Determination
2015
Related Article: K. Karrouchi, M. Ansar, S. Radi, M. Saadi, L. El Ammari|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|o890|doi:10.1107/S2056989015020071