6533b7d9fe1ef96bd126cd38
RESEARCH PRODUCT
Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from newborn rats
R E BakerJ. RuijterDe Bauke JongD. BingmannE.-j. Speckmannsubject
chemistry.chemical_elementNeocortexCalciumPharmacologyHippocampal formationMembrane PotentialsOrgan Culture TechniquesSeizuresMedicineAnimalsPentylenetetrazolFlunarizineMembrane potentialCerebral CortexNeuronsEpilepsyNeocortexbusiness.industryGeneral NeuroscienceNewbornRatsmedicine.anatomical_structurechemistryAnimals NewbornVerapamilCerebral cortexCalcium antagonistsVerapamilPentylenetetrazolebusinessNeuroscienceFlunarizinemedicine.drugdescription
Effects of the organic calcium antagonists verapamil and flunarizine on pentylenetetrazol induced paroxysmal depolarizations were tested in organotypic neocortical explants taken from neonatal rats. In these in vitro experiments the papaverin derivative verapamil depressed, and finally abolished, epileptic discharges in all cases. The piperazine derivative flunarizine, however, which is known to suppress epileptic discharges in hippocampal CA3 neurons (Bingmann and Speckmann 1986), showed no significant antiepileptic effects in the explanted neocortical neurons. Thus, the present findings may indicate that the suppressive action of flunarizine on the generation of paroxysmal depolarizations is restricted to distinct populations of neurons.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-09-01 | Experimental Brain Research |