6533b7d9fe1ef96bd126cdd4

RESEARCH PRODUCT

Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial

Aldert J. HooglandYolanda CastilloFemke Van DoesburgCristina BuiguesFrancisco Miguel Martínez-arnauOmar CauliPilar MolinaRosa Fonfría-vivasJulio Fernández-garridoLeo Pruimboom

subject

Malemedicine.medical_specialtyBODY-COMPOSITIONrespiratory muscles030209 endocrinology & metabolismPhysical exerciselcsh:TX341-641MASSPlaceboOBSTRUCTIVE PULMONARY-DISEASEelderlyArticlesarcopenia03 medical and health sciencesDOUBLE-BLIND0302 clinical medicineDouble-Blind MethodLeucineInternal medicineSTRENGTHRespiratory musclemedicineMUSCLE PROTEIN-SYNTHESISHumansAMINO-ACIDS030212 general & internal medicineVITAMIN-D SUPPLEMENTATIONEssential amino acidAgedchemistry.chemical_classificationAged 80 and overNutrition and Dieteticsbusiness.industryWHEY-PROTEINmedicine.diseaseClinical trialnutritionchemistrymuscle massSarcopeniaLean body massmuscle strengthFemaleLeucinePHYSICAL PERFORMANCEbusinesslcsh:Nutrition. Foods and food supplyFood Science

description

Treating sarcopenia in older individuals remains a challenge, and nutritional interventions present promising approaches in individuals that perform limited physical exercise. We assessed the efficacy of leucine administration to evaluate whether the regular intake of this essential amino acid can improve muscle mass, muscle strength and functional performance and respiratory muscle function in institutionalized older individuals. The study was a placebo-controlled, randomized, double-blind design in fifty participants aged 65 and over (ClinicalTrials.gov identifier NCT03831399). The participants were randomized to a parallel group intervention of 13 weeks&rsquo

yearjournalcountryeditionlanguage
2020-04-01Nutrients
10.3390/nu12040932https://www.mdpi.com/2072-6643/12/4/932