6533b7d9fe1ef96bd126ce4e
RESEARCH PRODUCT
The effect of β-mercaptoethanol on lactate dehydrogenase from rat brain
Vincenzo BonavitaRosa Guarnerisubject
PharmacologyHydrogen ionL-Lactate DehydrogenaseResearchBrainL-Lactate dehydrogenaseRat brainBiochemistryRatsCatalysisReaction ratechemistry.chemical_compoundchemistryBiochemistryLactate dehydrogenaseDehydrogenationSulfhydryl CompoundsMercaptoethanolNuclear chemistrydescription
Abstract Catalytic studies on lactate dehydrogenase from rat brain in the presence of β-mercaptoethanol have been performed. It has been found that pyruvate reduction and lactate dehydrogenation were differently affected by the addition of the sulfhydryl compound to the reaction mixture. The effect of β-mercaptoethanol on the catalyzed reaction has been shown to be dependent on the hydrogen ion concentration. When lactate dehydrogenation is measured, β-mercaptoethanol causes a net enhancement of the reaction rate at the more acidic pH values.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1963-10-01 | Biochemical Pharmacology |