6533b7d9fe1ef96bd126cf19

RESEARCH PRODUCT

Anti-16-kilodalton mycobacterial protein immunoglobulin M levels in healthy but purified protein derivative-reactive children decrease after chemoprophylaxis.

Mahavir SinghMarco Pio La MannaSimona BuccheriJurayi IvanyiAlfredo SalernoAmelia RomanoGuido SireciFrancesco ScarpaFrancesco DieliLucina TitonePaola Di CarloDiana Di LibertoPasquale Macaluso

subject

Microbiology (medical)TuberculosisAdolescentChaperoninsmedicine.medical_treatmentClinical BiochemistryImmunologyAntitubercular AgentsTuberculinEnzyme-Linked Immunosorbent AssayTuberculinChemopreventionImmunoglobulin GMicrobiologyKilodaltonMycobacterium tuberculosisBacterial ProteinsmedicineHumansTuberculosisImmunology and AllergyChildChemotherapyMycobacterium tuberculosis IgMpurified protein derivative chemoprophylaxisbiologybusiness.industryClinical and Diagnostic Laboratory ImmunologyMycobacterium tuberculosisbiology.organism_classificationmedicine.diseaseImmunoglobulin MImmunoglobulin MChild PreschoolImmunoglobulin GImmunologyChemoprophylaxisbiology.proteinbusiness

description

ABSTRACT Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti- M. tuberculosis HSP16 responses could assist in the management of pediatric TB.

http://hdl.handle.net/10447/13367