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RESEARCH PRODUCT

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Giuseppina CampisiMartina Iurato CarboneAlessia BartoloneRita ConiglioGiorgia CapocasaleLaura ManiscalcoVera PanzarellaVito Rodolico

subject

Pathologymedicine.medical_specialtyoptical coherencediagnosisHealth Toxicology and MutagenesisConcordancePemphigoid Benign Mucous Membraneimmune-mediated diseasestomographyArticlesymbols.namesakeOptical coherence tomographyBiopsymedicineHumansMedical diagnosisskin and connective tissue diseasesFisher's exact testmedicine.diagnostic_testintegumentary systembusiness.industryPemphigus vulgarisPublic Health Environmental and Occupational HealthRReproducibility of Resultsmedicine.diseaseGingivitiseye diseasesdesquamative gingivitisDesquamative gingivitisstomatognathic diseasessymbolsMedicineOral lichen planusbusinessTomography Optical CoherencePemphigus

description

Desquamative gingivitis (DG) denotes a heterogeneous immune-mediated disease for which early diagnosis represents a great challenge. The main aim of this study is to validate diagnostic concordance between specific Optical Coherence Tomography (OTC) patterns for DG related to oral Lichen Planus (OLP), Pemphigus Vulgaris (PV), and Mucous Membrane Pemphigoid (MMP) and definitive histological diagnosis. Forty-three patients with suspected immune-mediated DGs, were progressively recruited. Before biopsy, an OCT preliminary evaluation was performed using specific pre-determined OCT diagnostic patterns (i.e., morphology and localization of blisters, status of the basal membrane, epithelial thickness, presence/absence of acantholytic cells into blister and/or inflammatory infiltrate) related to OLP, PV and MMP. After histological confirmation, OCT and histological diagnoses were compared. Using pre-determined patterns, OCT diagnoses of DGs were: 22 (51%) OLP, of which 11 (26%) were with the bullous variant, 4 (9%) PV and 6 (14%) MMP. The same diagnoses were found by histological investigations (with the main OCT discriminatory potential for the bullous variant of OLP). The concordance between the two diagnostic methods was confirmed by the Fisher exact test (p-value &lt

yearjournalcountryeditionlanguage
2021-08-01International Journal of Environmental Research and Public Health
10.3390/ijerph18179095http://dx.doi.org/10.3390/ijerph18179095