6533b7dafe1ef96bd126d990

RESEARCH PRODUCT

Reduction of mdx mouse muscle degeneration by low-intensity endurance exercise: a proteomic analysis in quadriceps muscle of exercised versus sedentary mdx mice

Odessa SchillaciValentina Di LibertoVincenzo PerciavalleMarco GiallombardoNatale BelluardoSimona FontanaMonica FrinchiRiccardo AlessandroGiacomo De LeoGiuseppa MudòGiuseppe Morici

subject

MaleProteomicsmuscular dystrophymdx mousemedicine.medical_specialtycarbonic anhydrase exercise mdx muscle oxidative stress muscle proteomic muscular dystrophyBlotting Westerncarbonic anhydraseBiophysicsMuscle Proteinsmedicine.disease_causeBiochemistryQuadriceps Musclemuscle proteomicSuperoxide dismutaseWestern blotEndurance trainingInternal medicinemedicineAnimalsoxidative stressElectrophoresis Gel Two-DimensionalMuscular dystrophyMolecular BiologyOriginal Paperexercisebiologymedicine.diagnostic_testSuperoxide Dismutasebusiness.industryReproducibility of ResultsSkeletal muscleCell Biologymedicine.diseaseOriginal PapersCarbonic Anhydrase IIIMice Inbred C57BLMuscular Dystrophy Duchennemedicine.anatomical_structureEndocrinologyX-linked muscular dystrophy (mdx)carbonic anhydrase; oxidative stress; muscle proteomicMice Inbred mdxPhysical Endurancebiology.proteinCarbonic anhydrase 3businessmuscle oxidative stressOxidative stress

description

By proteomic analysis we found an up-regulation of four carbonic anhydrase-3 (CA3) isoforms and a down-regulation of superoxide dismutase [Cu-Zn] (SODC) in quadriceps of sedentary X-linked muscular dystrophy (mdx) mice as compared with wild–type (WT) mice and the levels were significantly restored to WT values following low-intensity endurance exercise.

yearjournalcountryeditionlanguage
2015-01-01
10.1042/bsr20150013http://hdl.handle.net/10447/126852