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RESEARCH PRODUCT
Transport, stability, and biological activity of resveratrol
Emeric LimagneEmeric LimagneFrédéric MazuéFrédéric MazuéDominique DelmasDominique DelmasPatrick DutartrePatrick DutartreVirginie AiresVirginie AiresFrançois GhiringhelliFrançois GhiringhelliNorbert LatruffeNorbert Latruffesubject
chemistry.chemical_classificationAntioxidantendocrine system diseasesMembrane transport proteinorganic chemicalsGeneral NeurosciencePhytoalexinmedicine.medical_treatmentfood and beveragesBiological activityMetabolismBiologyResveratrolGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundHistory and Philosophy of SciencechemistryBiotransformationBiochemistryIn vivobiology.proteinmedicineskin and connective tissue diseaseshormones hormone substitutes and hormone antagonistsdescription
Numerous studies have reported interesting properties of trans-resveratrol, a phytoalexin, as a preventive agent of several important pathologies: vascular diseases, cancers, viral infections, and neurodegenerative processes. These beneficial effects of resveratrol have been supported by observations at the cellular and molecular levels in both cellular and in vivo models, but the cellular fate of resveratrol remains unclear. We suggest here that resveratrol uptake, metabolism, and stability of the parent molecule could influence the biological effects of resveratrol. It appears that resveratrol stability involves redox reactions and biotransformation that influence its antioxidant properties. Resveratrol's pharmacokinetics and metabolism represent other important issues, notably, the putative effects of its metabolites on pathology models. For example, some metabolites, mainly sulfate-conjugated resveratrol, show biological effects in cellular models. The modifications of resveratrol stability, chemical structure, and metabolism could change its cellular and molecular targets and could be crucial for improving or decreasing its chemopreventive properties.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-01-01 | Annals of the New York Academy of Sciences |