6533b7dafe1ef96bd126e38d

RESEARCH PRODUCT

Evaluation of blood collection methods and anticoagulants for platelet function analyses on C57BL/6J laboratory mice

Cornelia KarwotAlexandra GrillChristoph ReinhardtKlytaimnistra KiouptsiKerstin Jurk

subject

0301 basic medicinePlatelet Function TestsP-selectin030204 cardiovascular system & hematologyPharmacologyC57bl 6jMice03 medical and health sciences0302 clinical medicineAnimalsHumansMedicinePlateletPlatelet activationmedicine.diagnostic_testbusiness.industryAnticoagulantsHematologyGeneral MedicineBlood collectionThromboelastographyMice Inbred C57BL030104 developmental biologyBlood Coagulation TestsbusinessPre activationFunction (biology)

description

The exploration of thrombotic mechanisms relies on the application of blood collection methods from laboratory mice with a minimal pre-activation of platelets and the clotting system. So far, very little is known on how the blood collection method and the anticoagulant used influence pre-activation of mouse platelets and coagulation. To determine the most suitable blood collection method, we systematically compared blood collection by heart puncture,

yearjournalcountryeditionlanguage
2019-12-08Platelets
https://doi.org/10.1080/09537104.2019.1701185