Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ)

6533b7dafe1ef96bd126ebff

RESEARCH PRODUCT

Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ)

Jorge Escorihuela Floris L. Van Delft Han Zuilhof Han Zuilhof Rickdeb Sen

subject

Kinetics 02 engineering and technology Metal-free click chemistry 010402 general chemistry Mass spectrometry 01 natural sciences Catalysis Química de superfícies VLAG Mass spectrometry Strain (chemistry)Bicyclic molecule Chemistry Communication Organic Chemistry General Medicine General Chemistry Cyclooctynes 021001 nanoscience & nanotechnology Organische Chemie Surface chemistry Combinatorial chemistry Communications Cycloaddition 0104 chemical sciences Quinone Kinetics Surface modification 0210 nano-technology Química orgànica

description

Abstract Strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non‐4‐yne (BCN) and surface‐bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART‐MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.

year	journal	country	edition	language
2017-02-15	Angewandte Chemie International Edition

https://doi.org/10.1002/anie.201612037

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