Pharmacokinetics of Droloxifene and Its Metabolites in Breast Cancer Patients

6533b7dafe1ef96bd126ed06

RESEARCH PRODUCT

Pharmacokinetics of Droloxifene and Its Metabolites in Breast Cancer Patients

K. Pollow H. J. Grill

subject

Adult Oncology Drug Cancer Research medicine.medical_specialty media_common.quotation_subject Administration Oral Biological Availability Antineoplastic Agents Breast Neoplasms Bioequivalence Breast cancer Pharmacokinetics Internal medicine medicine Humans Chromatography High Pressure Liquid Aged media_common Aged 80 and over business.industry Estrogen Antagonists Cancer Middle Aged Antiestrogen medicine.disease Tamoxifen Oncology Tolerability Droloxifene Drug Evaluation Female business Half-Life

description

Pharmacokinetics and metabolism of droloxifene, a new antiestrogenic drug, have been investigated by single- and multiple-dose studies in postmenopausal patients with advanced breast cancer. Short terminal elimination half-life, low accumulation, and improved drug tolerability are the most striking features of this safe and effective new antiestrogen. Bioequivalence of film-coated tablet, tablet, and standard solution of droloxifene has been shown. The concentrations of droloxifene and its metabolites have been determined by a highly selective HPLC method.

year	journal	country	edition	language
1991-01-01	American Journal of Clinical Oncology

https://doi.org/10.1097/00000421-199112002-00006

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