6533b7dafe1ef96bd126ee1a

RESEARCH PRODUCT

Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules

Adriana MillerJoanna WątłyHenryk KozłowskiMagdalena Rowinska-zyrek

subject

PeptidomimeticMetal ions in aqueous solutionAntimicrobial peptidesMetal binding sites010402 general chemistryPeptides Cyclic01 natural sciencesBiochemistryInorganic ChemistryPeptoidsHumansMoleculeAmino AcidsChelating Agentschemistry.chemical_classificationBinding SitesBacteria010405 organic chemistryMetal bindingStereoisomerismBiological activityAntimicrobialCombinatorial chemistryAnti-Bacterial Agents0104 chemical sciencesAmino acidchemistryAntimicrobial peptidesPeptidomimetics

description

The involvement of metal ions in interactions with therapeutic peptides is inevitable. They are one of the factors able to fine-tune the biological properties of antimicrobial peptides, a promising group of drugs with one large drawback - a problematic metabolic stability. Appropriately chosen, proteolytically stable peptidomimetics seem to be a reasonable solution of the problem, and the use of D-, β-, γ-amino acids, unnatural amino acids, azapeptides, peptoids, cyclopeptides and dehydropeptides is an infinite reservoir of metal binding motifs in metabolically stable, well-designed, biologically active molecules. Below, their specific structural features, metal-chelating abilities and antimicrobial potential are discussed.

yearjournalcountryeditionlanguage
2020-11-28Journal of Inorganic Biochemistry
https://doi.org/10.1016/j.jinorgbio.2021.111386