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RESEARCH PRODUCT
Neurodegeneration in multiple sclerosis: novel treatment strategies.
Felix LuessiVolker SiffrinFrauke Zippsubject
Multiple SclerosisInflammationNeuroprotectionmedicineAnimalsHumansPharmacology (medical)In patientMolecular Targeted TherapyNeuroinflammationNeuronsEvidence-Based Medicinebusiness.industryGeneral NeuroscienceMultiple sclerosisNeurodegenerationAnti-Inflammatory Agents Non-SteroidalNeurodegenerative Diseasesmedicine.diseasePathology of multiple sclerosisNeuroprotective AgentsTreatment strategyEducation Medical ContinuingNeurology (clinical)medicine.symptombusinessNeurosciencedescription
In recent years it has become clear that the neuronal compartment already plays an important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course of chronic neuroinflammation is a key factor in determining long-term disability in patients. Viewing MS as both inflammatory and neurodegenerative has major implications for therapy, with CNS protection and repair needed in addition to controlling inflammation. Here, the authors' review recently elucidated molecular insights into inflammatory neuronal/axonal pathology in MS and discuss the resulting options regarding neuroprotective and regenerative treatment strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-09-01 | Expert review of neurotherapeutics |