6533b7dbfe1ef96bd126ffa6
RESEARCH PRODUCT
Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
Mariachiara ZuccariniPatricia GiulianiValentina Di LibertoMonica FrinchiFrancesco CaciagliVanni CarusoRenata CiccarelliGiuseppa MudòPatrizia Di Ioriosubject
obesityAdipogenesisQH301-705.5Organic ChemistrySubcutaneous FatMesenchymal Stem CellsGeneral Medicinemetabolic disease/syndromeSettore BIO/09 - FisiologiaCatalysisComputer Science Applicationsadipose tissueInorganic ChemistryChemistrySettore BIO/14 - Farmacologiaadipose stromal/stem cells (ASCs)Adipose stromal/stem cells (ASCs) Adipose tissue Extracellular vesicles Metabolic disease/syndrome ObesityHomeostasisHumansPhysical and Theoretical ChemistryBiology (General)extracellular vesiclesMolecular BiologyQD1-999Spectroscopydescription
Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance of the con-tribution of ASC-derived EVs in the regulation of metabolic processes. In addition, we outlined the advantages/disadvantages of the use of EVs as potential next-generation anti-obesity agents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-01-28 | International Journal of Molecular Sciences |