6533b7dbfe1ef96bd12701b8

RESEARCH PRODUCT

Nano-Jewels in Biology. Gold and Platinum on Diamond Nanoparticles as Antioxidant Systems Against Cellular Oxidative Stress

José Raúl HeranceHermenegildo GarcíaVictor M. VictorCristina MenchónNadezda ApostolovaRoberto MartínMercedes Alvaro

subject

Materials scienceAntioxidantBiocompatibilityCell Survivalmedicine.medical_treatmentInorganic chemistryIntracellular SpaceGeneral Physics and Astronomychemistry.chemical_elementApoptosischemical and pharmacologic phenomenamedicine.disease_causePlatinum nanoparticlesAntioxidantsCatalysisCatalysischemistry.chemical_compoundMaterials TestingmedicineHumansGeneral Materials ScienceCell ProliferationPlatinumHydroxyl RadicalGeneral EngineeringGlutathioneOxidative StresschemistryNanoparticlesGoldParticle sizeDiamondPlatinumOxidative stressHeLa Cells

description

Diamond nanoparticles (DNPs) obtained by explosive detonation have become commercially available. These commercial DNPs can be treated under Fenton conditions (FeSO(4) and H(2)O(2) at acidic pH) to obtain purer DNP samples with a small average particle size (4 nm) and a large population of surface OH groups (HO-DNPs). These Fenton-treated HO-DNPs have been used as a support of gold and platinum nanoparticles (≤2 nm average size). The resulting materials (Au/HO-DNP and Pt/HO-DNP) exhibit a high antioxidant activity against reactive oxygen species induced in a hepatoma cell line. In addition to presenting good biocompatibility, Au/HO- and Pt/HO-DNP exhibit about a two-fold higher antioxidant activity than glutathione, one of the reference antioxidant systems. The most active material against cellular oxidative stress was Au/HO-DNP.

yearjournalcountryeditionlanguage
2010-10-14ACS Nano
https://doi.org/10.1021/nn1019412