6533b7dbfe1ef96bd1270a3c
RESEARCH PRODUCT
New diagnostic possibilities in systemic neonatal infections: metabolomics
Vassilios FanosMauro StronatiDiego GazzoloPierluigi CaboniAngelica DessìGiovanni CorselloRoberta Carbonisubject
medicine.medical_specialtyNeonatal infections; metabolomicsNeonatal sepsisbusiness.industryAcute-phase proteinInfant NewbornObstetrics and Gynecologymedicine.diseaseProcalcitoninSingle testSepsisNeonatal infectionMetabolomicsSettore MED/38 - Pediatria Generale E SpecialisticaSepsisPediatrics Perinatology and Child HealthmedicineHumansMetabolomicsbusinessIntensive care medicineComplicationNeonatal infectionBiomarkersdescription
Systemic neonatal infection is a serious complication in preterm and term infants and is defined as a complex clinical syndrome caused by bacteria, fungi and virus. Sepsis remains among the leading causes of death in both developed and underdeveloped countries above all in the neonatal period. Earlier diagnosis may offer the ability to initiate treatment to prevent adverse outcomes. There have been many studies on various diagnostic haematological markers like acute phase reactants, C-reactive protein, procalcitonin, interleukins and presepsin. However, there is still no single test that satisfies the criteria as being the ideal marker for the early diagnosis of neonatal sepsis. In this regard, metabolomic analysis seems to be a promising method for determining metabolic variations correlated with systemic neonatal infections.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 |