Rat CNS cell culture. Enhancement of neuronal survival and delay of glial proliferation by serum from patients with multiple sclerosis. A morphological study.

6533b7dbfe1ef96bd1270a49

RESEARCH PRODUCT

Rat CNS cell culture. Enhancement of neuronal survival and delay of glial proliferation by serum from patients with multiple sclerosis. A morphological study.

Giovanni Savettieri Alfredo Chiarini A. Cestelli Donatella Ferraro

subject

Central Nervous System medicine.medical_specialty Pathology Neurology Multiple Sclerosis Dermatology Biology Gliotoxin medicine Animals Cells Cultured Gliogenesis Neurons General Neuroscience Multiple sclerosis Embryo Cell Differentiation General Medicine Mycotoxins medicine.disease Embryo Mammalian In vitro Rats Psychiatry and Mental health Cell culture Organ Specificity Immunology Neurology (clinical)Neuroglia

description

The addition of serum from multiple sclerosis (MS) patients to the culture medium of dissociated cells from cerebral hemispheres of rat embryos caused a delay in glial proliferation and an enhancement of neuronal survival. Sera from normal individuals and patients with other neurological diseases failed to show this effect. These morphological observations are interpreted as the outcome of inhibition of in vitro gliogenesis.

year	journal	country	edition	language
1984-09-01	Italian journal of neurological sciences

10.1007/bf02043964 https://pubmed.ncbi.nlm.nih.gov/6209241

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