6533b7dbfe1ef96bd127156a
RESEARCH PRODUCT
Applicability of hybrid linear ion trap-high resolution mass spectrometry and quadrupole-linear ion trap-mass spectrometry for mycotoxin analysis in baby food.
Carla SolerJosep RubertJordi MañesKevin J. Jamessubject
Analytical chemistryMass spectrometryOrbitrapBiochemistryMass SpectrometryAnalytical ChemistryIonlaw.inventionBaby foodchemistry.chemical_compoundlawLimit of DetectionMSPDHumansQuadrupole ion trapMycotoxinQTRAPChromatography High Pressure LiquidChromatographyBaby foodOrganic ChemistryInfantGeneral MedicineMycotoxinsOrbitrapchemistryQuadrupoleInfant Fooddescription
Abstract Recent developments in mass spectrometers have created a paradoxical situation; different mass spectrometers are available, each of them with their specific strengths and drawbacks. Hybrid instruments try to unify several advantages in one instrument. In this study two of wide-used hybrid instruments were compared: hybrid quadrupole-linear ion trap-mass spectrometry (QTRAP ® ) and the hybrid linear ion trap-high resolution mass spectrometry (LTQ-Orbitrap ® ). Both instruments were applied to detect the presence of 18 selected mycotoxins in baby food. Analytical parameters were validated according to 2002/657/CE. Limits of quantification (LOQs) obtained by QTRAP ® instrument ranged from 0.45 to 45 μg kg −1 while lower limits of quantification (LLOQs) values were obtained by LTQ-Orbitrap ® : 7–70 μg kg −1 . The correlation coefficients ( r ) in both cases were upper than 0.989. These values highlighted that both instruments were complementary for the analysis of mycotoxin in baby food; while QTRAP ® reached best sensitivity and selectivity, LTQ-Orbitrap ® allowed the identification of non-target and unknowns compounds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 | Journal of chromatography. A |