The role of targeted therapy for gastrointestinal tumors

6533b7dbfe1ef96bd1271574

RESEARCH PRODUCT

The role of targeted therapy for gastrointestinal tumors

Antonio Russo Konstantinos Papadimitriou Giovanni Sortino Eugenio Fiorentino Christian Rolfo Francesco Passiglia Giuseppe Bronte Ghada Marogy Marc Peeters

subject

Sorafenib Oncology Vascular Endothelial Growth Factor A medicine.medical_specialty Receptor ErbB-2 Hepatocellular carcinoma Settore MED/06 - Oncologia Medica medicine.medical_treatment Antineoplastic Agents Neuroendocrine tumors Targeted therapy Targeted therapy chemistry.chemical_compound Neuroendocrine tumor Trastuzumab Internal medicine Regorafenib medicine Humans Gastrointestinal tumors Molecular Targeted Therapy Protein Kinase Inhibitors Gastrointestinal Neoplasms Everolimus Hepatology Sunitinib business.industry Colorectal cancer; Gastric cancer; Gastrointestinal tumors; Hepatocellular carcinoma; Neuroendocrine tumors; Targeted therapy; Hepatology; Gastroenterology Gastrointestinal tumor Gastroenterology Cancer medicine.disease Colorectal cancer ErbB Receptors Receptors Vascular Endothelial Growth Factor chemistry Human medicine Neuroendocrine tumors business Gastric cancer medicine.drug

description

Abstract: Many targeted drugs have been studied to target the molecular pathways involved in the development of gastrointestinal cancers. Anti-VEGF, anti-EGFR agents, and recently also multi-kinase inhibitor regorafenib, have already been available for the treatment of metastatic colorectal cancer patients. To date, Her-2 positive, gastric cancer patients, are also treated with trastuzumab, while the multi-targeted inhibitor, sorafenib, represents the standard treatment for hepatocellular carcinoma patients. Finally, sunitinib and everolimus, have been approved for the treatment of the neuroendocrine gastroenteropancreatic tumors. Actually a great number of further drugs are under preclinical and clinical development. The aim of this review is to provide a comprehensive overview of the state of art, focusing on the new emerging strategies in the personalized treatment of gastrointestinal tumors.

year	journal	country	edition	language
2014-01-01

10.1586/17474124.2014.922870 http://hdl.handle.net/10447/109880

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