6533b7dbfe1ef96bd1271614
RESEARCH PRODUCT
In vivo inhibition of AChE activity in the European eel Anguilla anguilla exposed to technical grade fenitrothion.
Encarna SanchoM.d. FerrandoEnrique J. Andreusubject
medicine.medical_specialtyInsecticidesTime FactorsAchéImmunologyFenitrothionToxicologychemistry.chemical_compoundIn vivoInternal medicinemedicineAnimalsPharmacologychemistry.chemical_classificationDose-Response Relationship DrugFenitrothionPesticideAnguillaAcetylcholinesteraselanguage.human_languageEnzymeEndocrinologychemistryToxicitylanguageTechnical gradeAcetylcholinesteraseCholinesterase Inhibitorsdescription
European eel (Anguilla anguilla) were exposed to sublethal fenitrothion concentrations in a continuous flow-through system for 4 days. Plasma acetylcholinesterase (AChE) activity was evaluated after 2, 8, 12, 24, 32, 48, 56, 72 and 96 h pesticide exposure. AChE activity in the plasma of the eel decreased as concentration of fenitrothion increased. Pesticide induced significant inhibitory effects on the AChE activity of A. anguilla ranging from 51% inhibition at sublethal concentration of 0.02 ppm to 57% inhibition at sublethal concentration of 0.04 ppm. Eel were exposed to both fenitrothion concentrations for 96 h and then allowed a period of recovery in pesticide-free water. Following 1 week of recovery, the AChE activity for those animals previously exposed to fenitrothion was still different from the controls. Animals transferred to clean water showed plasma AChE activities reduced in a 34 and 51% when previously exposed to 0.02 and 0.04 ppm pesticide, respectively. This is probably due because regeneration of the enzyme is mainly by the novo synthesis after exposure to organophosphates and levels need a large extent to recover.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-11-25 | Comparative biochemistry and physiology. Part C, Pharmacology, toxicologyendocrinology |