6533b7dcfe1ef96bd1271e89

RESEARCH PRODUCT

Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions

Svenja MorsbachVolker MailänderVolker MailänderSeraphine V. WegnerHans-jürgen ButtTanja WeilDoris VollmerKurt KremerNoemí EncinasKatharina LandfesterSi WuSeah Ling KuanKaloian KoynovRüdiger BergerGrazia GonellaMischa BonnTobias WeidnerTobias WeidnerTristan Bereau

subject

Surface (mathematics)Protein FoldingMaterials scienceSurface PropertiesengineeringReviewsNanotechnology02 engineering and technologyReview010402 general chemistryProtein Engineering01 natural sciencesCatalysisBiological fluidTheranostic NanomedicineNanomaterialsinterfacesAdsorptionPlanarCharacterization methodscharacterizationnanomaterialsDrug CarriersProteinsGeneral Chemistry021001 nanoscience & nanotechnologyprotein adsorption0104 chemical sciencesCharacterization (materials science)NanostructuresProtein Corona0210 nano-technologyProtein adsorptionProtein Binding

description

Abstract Once materials come into contact with a biological fluid containing proteins, proteins are generally—whether desired or not—attracted by the material's surface and adsorb onto it. The aim of this Review is to give an overview of the most commonly used characterization methods employed to gain a better understanding of the adsorption processes on either planar or curved surfaces. We continue to illustrate the benefit of combining different methods to different surface geometries of the material. The thus obtained insight ideally paves the way for engineering functional materials that interact with proteins in a predetermined manner.

10.1002/anie.201712448http://europepmc.org/articles/PMC6391961