Antiproliferative Oleanane Saponins from Meryta denhamii

6533b7dcfe1ef96bd1271ef7

RESEARCH PRODUCT

Antiproliferative Oleanane Saponins from Meryta denhamii

Fabrizio Dal Piaz Francesco De Simone Giuseppina Cioffi Antonio Vassallo Nunziatina De Tommasi Fabio Venturella Paolo De Caprariis

subject

Stereochemistry Saponin Pharmaceutical Science Pharmacognosy Analytical Chemistry Mice chemistry.chemical_compound Triterpene Drug Discovery Animals Humans Meryta denhamii Oleanolic Acid Araliaceae Nuclear Magnetic Resonance Biomolecular Oleanane Pharmacology chemistry.chemical_classification Plants Medicinal Molecular Structure biology Organic Chemistry Glycoside Saponins biology.organism_classification Antineoplastic Agents Phytogenic Settore CHIM/08 - Chimica Farmaceutica Oleanane Saponins Antiproliferative effects Terpenoid Italy Complementary and alternative medicine chemistry Biochemistry Settore BIO/14 - Farmacologia Molecular Medicine Drug Screening Assays Antitumor Two-dimensional nuclear magnetic resonance spectroscopy

description

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

year	journal	country	edition	language
2008-01-01	Journal of Natural Products

https://doi.org/10.1021/np8000464

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