6533b7dcfe1ef96bd1271fc1
RESEARCH PRODUCT
Hepatitis C virus associated primary hepatocellular carcinoma in a noncirrhotic liver
K H Meyer Zum BüschenfeldeG. GerkenStephan ImmenschuhWolfgang HerrH. SchwickertThomas PorallaPeter SchirmacherK. W. Steegmüllersubject
Malemedicine.medical_specialtyCarcinoma HepatocellularCirrhosisHepatitis C virusHepacivirusmedicine.disease_causeGastroenterologyViruschemistry.chemical_compoundRisk FactorsInternal medicineDrug DiscoverymedicineHumansHepatitis AntibodiesHepatitis B AntibodiesThorotrastGenetics (clinical)AgedHepatitis B virusbiologybusiness.industryIncidenceLiver NeoplasmsGeneral Medicinemedicine.diseaseHepatitis Cdigestive system diseaseschemistryHepatocellular carcinomabiology.proteinRNA ViralMolecular MedicineAntibodybusinessNodular regenerative hyperplasiadescription
The case of a 71-year-old man with a primary hepatocellular carcinoma in a non-cirrhotic liver is reported. There were no risk factors of hepatocellular carcinoma (HCC)-like liver cirrhosis, alcohol drinking, tobacco smoking, exposure to vinyl chloride, thorotrast, aflatoxin or alpha 1-antitrypsin deficiency. Serologically, the patient was positive for antibodies to the hepatitis B virus (anti-HBc, anti-HBs) and for anti-hepatitis C virus (HCV) antibodies. Virologically, positive and negative strands of HCV RNA could be detected in the patient's serum and tumorous liver tissue by reverse transcription polymerase chain reaction as a sign of persistent HCV replication. Histologically, the HCC was completely surrounded by liver tissue which showed the signs of nodular regenerative hyperplasia. Indeed, the mechanism of hepatocarcinogenesis remains to be clarified. However, this case supports the observation that HCC may also develop in patients with HCV infection without preexisting liver cirrhosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 | The Clinical Investigator |