6533b7dcfe1ef96bd1271ffb
RESEARCH PRODUCT
Jaw osteonecrosis management around a dental implant inserted 2 years before starting treatment with zoledronic acid
Alberto Jiménez-burkhardtAna-belén Marín-fernándezBlas García MedinaAntonio Aguilar-salvatierraGerardo Gómez-morenosubject
Peri-implantitisBone diseasemedicine.medical_treatmentDifosfonatosDentistryCase Report:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Peri-implantitisDental implant:Chemicals and Drugs::Organic Chemicals::Organophosphorus Compounds::Diphosphonates [Medical Subject Headings]Implantes dentales:Anatomy::Cells::Connective Tissue Cells::Macrophages::Osteoclasts [Medical Subject Headings]ImidazolesOsteonecrosisBisphosphonates:Diseases::Neoplasms [Medical Subject Headings]:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludNeoplasiasHumanosmedicine.anatomical_structureNeoplasias de la mama:Chemicals and Drugs::Biomedical and Dental Materials::Dental Materials::Dental Implants [Medical Subject Headings]UNESCO::CIENCIAS MÉDICASMaxillectomy:Diseases::Stomatognathic Diseases::Mouth Diseases::Peri-Implantitis [Medical Subject Headings]Oral SurgeryResorción óseamedicine.drugmedicine.medical_specialtyOdontología:Diseases::Musculoskeletal Diseases::Bone Diseases::Osteonecrosis [Medical Subject Headings]Bone resorptionBreast cancerOsteoclast:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Azoles::Imidazoles [Medical Subject Headings]medicinePeriimplantitisGeneral DentistryZoledronic acid:Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings]Osteonecrosis of the jawbusiness.industry:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Bone Remodeling::Bone Resorption [Medical Subject Headings]Osteoclastosmedicine.diseaseSurgeryZoledronic acid:Check Tags::Female [Medical Subject Headings]Osteonecrosis of the jawbusinessdescription
Journal Article; Bisphosphonates (BP) are a type of drug known to inhibit bone resorption through complex interventions. Their primary mechanism of action is aimed at the cellular level, inhibiting osteoclast activity and so bone resorption. BPs are widely used, with many patients receiving continuous treatment for years. But it is well known that these drugs can produce osteonecrosis of the jaw (ONJ). Zoledronic acid (ZA) is an intravenous BP used in the treatment and prophylaxis of bone disease in patients with malignant tumors with bone implication. ZA is the most potent BP in clinical development. This report describes the case of a 62-year-old woman with breast cancer antecedents which relapsed, who had received a maxillary dental implant two years before the start of therapy with zoledronic acid. She later developed osteonecrosis of the jaw (ONJ), which began in the peri-implant area, and was treated for stage 3 ONJ by sub-total maxillectomy. Key words:Bisphosphonates, zoledronic acid, osteonecrosis of the jaw, peri-implantitis, maxillectomy. Yes
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-07-01 | Journal of Clinical and Experimental Dentistry |